Sangeeta Bhatia, M.D., Ph.D.
Director, Laboratory for Multiscale Regenerative Technologies

Dr. Bhatia is a Howard Hughes Medical Institute Investigator and a Professor of Health Sciences and Technology (HST) and Electrical Engineering and Computer Science (EECS) at the Massachusetts Institute of Technology. She is a member of the Koch Institute for Integrative Cancer Research and the Harvard Stem Cell Institute, an Associate member of the Broad Institute, and a Biomedical Engineer at the Brigham & Women's Hospital. The research in her laboratory is focused on the applications of micro- and nanotechnology for tissue repair and regeneration.
More about Dr. Bhatia...
Dr. Bhatia trained at Brown, MIT, Harvard, and MGH. She was a member of the Bioengineering Department at University of California at San Diego for 6 years. She has been awarded the David and Lucile Packard Fellowship given to "the nation's most promising young professors in science and engineering," the MIT TR100 Young Innovators Award, the Global Indus Technovator Award, and been named one of Massachusetts' 'Women to Watch'. She is a Fellow of the American Institute for Medical and Biological Engineering and of the American Society for Clinical Investigation. She co-authored the first undergraduate textbook on tissue engineering and is a frequent advisor to governmental organizations on nanobiotechnology, biomedical microsystems, and tissue engineering. She is the co-founder of two startup companies. She holds 15 issued or pending patents and has worked in industry at Pfizer, Genetics Institute, ICI Pharmaceuticals, and Organogenesis.

Education
M.D., Harvard Medical School;
Ph.D., Biomedical Engineering, Massachusetts Institute of Technology; Harvard-MIT Division of Health Sciences and Technology;
M.S., Mechanical Engineering, Massachusetts Institute of Technology;
B.S., Biomedical Engineering, Brown University;

E-mail:
sbhatia@mit.edu

Sue Kangiser, Administrative Assistant
kangiserI am the administrative assistant of Sangeeta Bhatia and LMRT. I grew up in California, New Jersey, and Texas, and received my B.S. in Psychology from U.T. Austin and M.S. in Educational Psychology from Texas A&M University. I started working at M.I.T. in 2000 and joined the LMRT group in 2005.
E-mail: kangiser@mit.edu
Steve Katz, Lab Manager
katz A native Bostonian, I received my Bachelor's degree in biology from Bates College in 1991. For the past 15 years I have worked in both academia and industry researching the molecular mechanisms of cancer, congestive heart failure, and diabetes. In the summer of 2006 I joined LMRT as lab manager.
E-mail: stevek@mit.edu
Greg Underhill, Post-Doctoral Researcher
underhillI received my B.S. in Chemical Engineering in 1997 and Ph.D. in Biomedical Engineering in 2003, both from Northwestern University. My thesis work was performed in the laboratory of Dr. Geoffrey Kansas in the department of Microbiology-Immunology and focused on the adhesive properties and chemotactic responsiveness of antibody secreting plasma cells, as well as the gene expression alterations underlying plasma cell differentiation. In LMRT, we are interested in cell-cell interactions within the liver microenvironment and the differentiation of bipotential hepatic stem cells as a basis for tissue engineered structures.
E-mail: gunderhi@mit.edu
Sandra March-Riera, Post-Doctoral Researcher
marchI received my PhD in Cell Biology for work focused on the biology of hepatic stellate cells and its role in liver pathophysiology. In the Bhatia Laboratory, I am interested in understanding the reciprocal interactions between hepatocyes and endothelial cells at cellular and molecular levels.
E-mail: smarch@mit.edu
David Wood, Post-Doctoral Researcher
woodI received my B.S. (Physics) from NC State University in 2001, and I received my Ph.D. (Physics) from UC Santa Barbara in 2007. I did my thesis work with Andrew Cleland, developing high throughput electronic particle analysis for microfluidic systems.
My work at LMRT is focused on solving relevant problems in tissue engineering and medicine using microtechnology and microfluidics. Currently, we are working to develop a high throughput assay for screening DNA damage in single cells. This technology will enable large scale studies of the effects of environmental factors on cellular DNA damage and repair capacity. Additionally, I am working on new methods to build vasculature for in vitro liver tissue constructs, which will improve their long term viability.
E-mail: dkwood@mit.edu
Neetu Singh, Post-Doctoral Researcher
singhI received my Ph.D. in Chemistry from Georgia Institute of Technology in 2008 working with Prof. L. Andrew Lyon on developing novel synthetic routes towards the design of hydrogel nanoparticles with structural and chemical complexities that can be easily interfaced with biological systems relevant to biomedicine. Here at MIT's LMRT, I have been interested in developing nanomaterials for achieving and investigating RNAi therapy.
E-mail: sneetu@mit.edu
Alice Chen, Graduate Student
chen Alice Chen received a B.S. degree in Bioengineering from UC Berkeley in 2003. From 2001-2003, Alice worked at the Lawrence Livermore National Laboratory (LLNL) in the biotechnology and microtechnology departments on projects ranging from epidemiology studies for elucidating mechanisms of cancer to device design/testing for gene synthesis and miniaturized PCR. After graduation, Alice joined the Biodefense division of LLNL as a Biomedical scientist. Her research focused on direct delivery of modified siRNA for gene silencing and on the development of a pressure-based platform for capturing and sustaining single cells.

Alice is currently pursuing a doctoral degree in the Division of Health Sciences & Technology at MIT and the School of Engineering and Applied Sciences at Harvard University. She is interested in the application of novel biomaterials and nanotechnologies to tissue engineering, and her research focuses on the development and assessment of 3D implantable, hepatic tissues. She is supported by NSF and NDSEG graduate research fellowships.
Email: aachen@mit.edu

Kelly Stevens, Graduate Student
chen Kelly R. Stevens was born in New Richmond, Wisconsin. She received her Bachelor of Science degree in Biomedical Engineering from the University of Wisconsin-Madison. While at the University of Wisconsin-Madison, she worked in the laboratory of Dr. Weiyuan John Kao to study the inflammatory response to gelatin-based biodegradable hydrogels. Prior to attending graduate school, she worked in the Stent R&D and Applied Research groups at Boston Scientific in Minneapolis, Minnesota. She earned her Doctor of Philosophy from the Department of Bioengineering at the University of Washington under the guidance of Dr. Charles E. Murry in 2008. Her thesis work focused on controlling cell proliferation and tissue formation for myocardial repair. Kelly is interested in using tools in cellular and molecular biology, nano/microscale engineering, and biomaterials science to advance stem cell biology and regenerative medicine. Her work in the Bhatia Laboratory focuses on studying cell-cell interactions in three-dimensional engineered liver tissue.
Email: stevensk@mit.edu

Geoffrey von Maltzahn, Graduate Student
vonmaltzahn Geoffrey von Maltzahn was born in Arlington, TX, graduated from Thomas Jefferson High School for Science and Technology in Fairfax, VA, and studied chemical and biomedical engineering for his S.B. degree at MIT. During his time at MIT, Geoffrey joined Dr. Shuguang Zhang"s Laboratory of Molecular Self-assembly and spent three years designing and developing a new class of self-assembling surfactant peptides. In recognition of this research he was awarded the 2003 MIT Randolph G. Wei Award for "MIT's most outstanding contribution in undergraduate research at the interface of the life sciences and engineering' along with the MIT Robert T. Haslam Cup for "outstanding professional promise in Chemical Engineering." He also received the Johnson & Johnson/MIT Excellence in Biomedical Engineering Research Prize, was profiled as a 'Whiz Kid' in The Journal of New England Technology, and had the honor of presenting his research and representing all of MIT's NSF-funded undergraduate students to members of the U.S. Congress at the 2003 Coalition for NSF Funding in Washington, DC.

Geoffrey is currently designing mechanisms for temporally controlling the self-assembly of nanoparticles in his doctoral research in the Health Sciences and Technology Division at MIT with the support of Whitaker and NSF Doctoral Fellowships. He strongly believes that by applying engineering fundamentals to the problems of targeting and imaging cancer, clever and effective treatments can be devised.
E-mail: gvonmalt@mit.edu

Yin Ren, Graduate Student
shanYin went to Vincent Massey Secondary School in Windsor, Ontario, Canada, and graduated from MIT in 2006 with a S.B. degree in electrical and biomedical engineering. While at MIT, he worked in Prof. Jongyoon Han's laboratory designing and developing microfluidic devices for protein separation and preconcentration. He also worked in the radiation oncology physics division at MGH and University of Michigan, developing a respiratory-gated integrated radiation therapy system.

Yin is currently pursuing a MD-PhD degree in the Medical Scientist Training Program at Harvard Medical School and in the Division of Health Sciences and Technology at MIT. He is interested in the application of nanotechnologies to human disease, such as cancer. He hopes to engineer novel nanomaterials to better image, target and deliver therapeutics to various disease processes.
Email: yinren@mit.edu
Jing (Meghan) Shan, Graduate Student
shan Meghan went to high school in Canada, where she was a National Gold Medallist in the Canadian Fermat Mathematics Competition. She graduated Summa Cum Laude from Columbia University, NYC, in May 2007 with a B.S. in Biomedical Engineering. As an undergraduate, Meghan did research at the Biomaterial and Interface Tissue Engineering Laboratory, studying how osteoblast-fibroblast interactions modulate cell phenotypes via autocrine and paracrine regulations. She also held a research fellowship at the Mayo Clinic in Rochester, MN. At Columbia, she was named the MacLaren Scholar and received the Claire S. and Robert E. Reiss Prize for graduating seniors judged most likely to contribute substantially to the Biomedical Engineering field.

Currently, Meghan is doing research with miniature in vitro liver models, using them for high-throughput screens with applications in compound safety testing, hepatic tissue engineering and liver regeneration.
Email: js8686@mit.edu

Nathan Reticker-Flynn, Graduate Student
retickerNate received his Bachelor's in Mechanical Engineering from Tufts University in 2006. His undergrad research focused on the use of ultrasound to characterize the stiffness matrix of anisotropic materials (in particular, Grenadilla wood). He received is Master's in Mechanical Engineering from Massachusetts Institute of Technology in 2008, where his research focused on the use of the thermosensitive hydrogel poly(NIPAAm) in microfluidic valves. At LMRT, Nate is working on a microfluidic platform for analyzing the adhesion of circulating tumor cells (CTCs) to various types of matrix molecules and their growth in response to various soluble factors.
Email: nathanrf@mit.edu
David Braga Malta, Graduate Student
bragaDavid received his MSc in Biological Engineering in 2007 from IST (Instituto Superiror Técnico), Lisboa, Portugal. Now he is pursuing his PhD within the MIT Portugal Program working at LMRT at MIT and SCBL at IST. His research focuses on the bone marrow microenvironment and the interactions between mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC). He aims at the clarification of the mechanisms of the niche that control the stem cell pool towards the ex vivo large scale expansion of HSC.
Email: dmalta@mit.edu
Kartik Trehan, Graduate Student
trehanKartik was born in New York where he attended Ward Melville High School. He received his B.S. in Biomedical Engineering and Applied Mathematics from Johns Hopkins University in 2007, followed by an M.S.E. in Biomedical Engineering and an M.S.E. in Applied Mathematics also from Johns Hopkins in 2008. He was awarded the Richard J. Johns Award by the Department of Biomedical Engineering and the AM&S Achievement Award by the Department of Applied Mathematics and Statistics for outstanding academic achievement.

Kartik's research experience at Johns Hopkins included tissue engineering scaffold design for blood vessel and peripheral nerve regeneration under Dr. Hai-Quan Mao, statistical signal analysis for characterizing the nanostructure of actin-based motility under Drs. Scot Kuo and Carey Priebe, bioimpedance-measuring instrumentation for the detection of preterm labor under Drs. Robert Allen and Edith Gurewitsch, and pull-out resistant orthopedic pedicle screws for osteoporotic patients under Dr. Jay Khanna. His work has culminated in several publications, patents, and scientific awards.

As a National Science Foundation Graduate Research Fellow, Kartik is pursuing a doctorate in Medical Engineering and Medical Physics from the Harvard-MIT Division of Health Science and Technology. His present research involves the design of regenerative technologies, particularly for the liver, and he sees his position at Harvard and MIT more broadly as an opportunity to contribute his best to the advancement of human health.

Kartik is grateful for the strong role his research and academic advisors have played in his scientific development. He is most thankful however for the continued support of his family and mentor to whom he attributes his progress.
Email: enzyme@mit.edu
Kevin Yu-Ming Lin, Graduate Student
linKevin Lin received his B.S.E. in Chemical Engineering from the University of Michigan, Ann Arbor in 2008. ÊHe is currently pursuing a doctoral degree in the Chemical Engineering Department at MIT. ÊHis research is focused on the development of multifunctional nanocarriers for the diagnosis and treatment of cancer.
Email: kylin@mit.edu
Cheri Yingjie Li, Graduate Student
liCheri received her B.S. in chemical engineering from Stanford University in 2004. While at Stanford, her undergraduate thesis work with Professor Curtis Frank focused on protein diffusion through temperature-sensitive hydrogels. She was also a Merck Engineering & Technology Fellow and interned at Merck during the summers of 2006 and 2007. Cheri is currently a Ph.D. candidate in chemical engineering at MIT, supported by the NSF and NDSEG graduate fellowships. Her research interests include applying polymer materials to problems in tissue engineering.
Email: cheriyli@mit.edu
Caitlin Berrigan, Artist in Residence
berriganCaitlin Berrigan is a visual artist and Master's candidate in the MIT Visual Arts Program. Her practice is conceptual, carried by material things: tactile and edible sculpture, immersive installation, electronic media and participatory performance. Berrigan's work is driven by the intimate and complex relationships we have with the environment, the interwoven narratives of technoscience and culture, the molecular, the viral, the grotesque, the unnerving spaces of the body and social responsibility. She is interested in the poetic space of disjuncture produced by mixing critical social issues with humor, irony, disgust and ambiguity. To make politicized subjects palpable in an artwork releases them from our normalized encounters, creates rupture, and hopefully inspires a new - if unresolved - way to approach them.

Berrigan has presented her work in the Whitney Museum's Initial Public Offerings, Storefront for Art & Architecture, Gallery 400 Chicago, Anthology Film Archives and SIGGRAPH among many other venues and festivals. She has given lectures at institutions such as the New Museum, Harvard Medical School, and the Max Planck Institute. She is the recipient of several grants and prizes including the MIT Schnitzer Prize in Art, Skowhegan Agnes Gund Fellowship, and MIT Schlossman Fellowship. She is a Master's candidate in Visual Studies at M.I.T. and received her B.A. in art production and art history from Hampshire College in Amherst, MA. She attended the Skowhegan School of Painting & Sculpture and was artist-in-residence at the RPI BioArts Initiative and the Experimental Television Center.
Email: berrigan@mit.edu