| Peter
Dedon, M.D., Ph.D.
Professor
of Toxicology and Biological Engineering
Associate Head, Department of Biological Engineering
Deputy Director, MIT Center for Environmental
Health Sciences
Research group
web site
Email: pcdedon@mit.edu
Office: NE47-277
Phone: 617-253-8017
Fax: 617-324-7554
Administrative Assistant: Kristine Marzilli
Office: NE47-257
Phone: 617-324-7555
Courses: BE.201, BE.400
Recent Publications
Click
here for a list of recent publications.
Dong, M. and P.C. Dedon (2006) Relatively small increases
in the steady-state levels of nucleobase deamination products
in DNA from human TK6 cells exposed to toxic levels of
nitric oxide. Chem. Res. Toxicol. 19 : 50-57.
Li, C.-Q., B. Pang, T. Kiziltepe, L.J. Trudel, B.P. Engelward,P.C.
Dedon, and G.N. Wogan (2006) Threshold cytotoxicity and
genotoxicity induced by nitric oxide in human lymphoblastoid
cells expressing wild-type or null p53. Chem. Res. Toxicol.,
in press.
Dedon, P. (2005) Diverse mechanisms of endogenous nucleobase
deamination in DNA and RNA, in Advances in Molecular Toxicology,
ed. J. Fishbein, Wiley, NY, in press.
Dong, M., V. Vongchampa, L. Gingipalli, J.-F. Cloutier,
Y.W. Kow, T. O'Connor and P.C. Dedon (2005) Development
of enzymatic probes of oxidative and nitrosative DNA damage
caused by reactive nitrogen species. Mut. Res. Nov
4; [Epub ahead of print]
Zhou, X., K. Taghizadeh and P. Dedon (2005) Chemical
and biological evidence for base propenals as the major
source of the endogenous M 1dG adduct in cellular DNA. J.
Biol. Chem. 280 : 25377-25382.
Zhou, X., R. Liberman, P. Skipper, Y. Margolin, S. Tannenbaum,
P.Dedon (2005) Quantification of DNA strand breaks and
abasic sites by oxime derivatization and accelerator mass
spectrometry: Application to g -radiation and peroxynitrite. Anal.
Biochem. 343 : 84-92.
Li, C.-Q., T.L. Wright, M. Dong, Y.E.M. Dommels, P.C.
Dedon, S.R. Tannenbaum, and G.N. Wogan (2005) Biological
role of glutathione in nitric oxide-induced toxicity in
cell culture and animal models. Free Rad. Biol. Med. 39 :
1489-1498.
Kiziltepe, T., A. Yan, M. Dong, V.S. Jonnalagadda, P.C.
Dedon, and B.P. Engelward (2005) Delineation of the chemical
pathways underlying nitric oxide-induced homologous recombination
in mammalian cells. Chem. Biol. 12 : 357-369.
Kim, M.Y., M. Dong, P.C. Dedon and G.N. Wogan (2005)
Effects of peroxynitrite dose and dose-rate on DNA damage
and mutation in the supF shuttle vector. Chem.
Res. Toxicol., 18: 76-86.
Collins, C., X. Zhou, R. Wang, M. Barth, T. Jiang, J.
Coderre and P. Dedon (2005) Differential oxidation of deoxyribose
in DNA by g - and a -radiation. Rad. Res., 163:
654-662.
Chen, B., T. Bohnert, X. Zhou and P. Dedon (2004) 5'-(2-Phosphoryl-1,4-dioxobutane)
as a product of 5'-oxidation of deoxyribose in DNA: Elimination
as trans-1,4-dioxo-2-butene and approaches to analysis. Chem.
Res. Toxicol., 17 :1406-1413.
Bohnert, T., L. Gingipalli, P.C. Dedon (2004) Reaction
of 2'-deoxyribonucleosides with cis- and trans-1,4-dioxo-2-butene. Biochem.
Biophys. Res. Commun., 323: 838-844.
Dedon, P.C. and S.R. Tannenbaum (2004) Reactive nitrogen
species in the chemical biology of inflammation. Arch.
Bioch. Biophys., 423 : 12-22.
Collins, C., M. Awada, X. Zhou and P.C. Dedon (2003)
Analysis of 3'-phospho-glycolaldehyde residues in oxidized
DNA by gas chromatography/negative chemical ionization/mass
spectrometry. Chem. Res. Toxicol., 16 :
1560-1566.
Dong, M., C. Wang. W.M. Deen, P.C. Dedon (2003) Absence
of 2'-deoxyo-xanosine and presence of abasic sites in DNA
exposed to nitric oxide at controlled physiological concentrations.Chem.
Res. Toxicol. 16 : 1044-1055. |
