Peter Dedon, M.D., Ph.D.
Professor of Toxicology and Biological Engineering
Associate Head, Department of Biological Engineering
Deputy Director, MIT Center for Environmental
Health Sciences

Research group web site

Email: pcdedon@mit.edu
Office: NE47-277
Phone: 617-253-8017
Fax: 617-324-7554
Administrative Assistant: Kristine Marzilli
Office: NE47-257
Phone: 617-324-7555

Courses: 20.201, 20.440, 5.54

Recent Publications

Lim, C.-H., P.C. Dedon and W.M. Deen (2008) Kinetic analysis of intracellular concentrations of reactive nitrogen species.  Chem. Res. Toxicol., in press.

Taghizadeh, K., J.L. McFaline, B. Pang, M. Sullivan, M. Dong, E. Plummer, and P.C. Dedon (2008) Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry.  Nat. Protocols, 3: 1287-1298.

Meira, L.B., J.M. Bugni, S.L. Green, C.-W. Lee, B. Pang, D. Borenshtein, B.H. Rickman, A.B. Rogers, C.A. Moroski, J.L. McFaline, D.B. Schauer, P.C. Dedon, J.G. Fox and L.D. Samson (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis. J. Clin. Invest., 118: 2516-2525.

Ringvoll, J., M.P. Nabong, L.M. Nordstrand, L.B. Meira, B. Pang, A. Bekkelund, P.C. Dedon, S. Bjelland, L.D. Samson, P.Ø. Falnes, and A. Klungland (2008) AlkB homolog 2 (ABH2) is the principle dioxygenase for repair of ethenoadenine lesions in mammalian DNA.  Cancer Res., 68: 4142-4149.

Son, J., B. Pang, J. McFaline, K. Taghizadeh, P.C. Dedon (2008) Surveying the damage: The challenges of developing nucleic acid biomarkers of inflammation.  Molecular Biosys., 4: 902-908.

Lee, Y.A., A. Durandin, P.C. Dedon, N.E. Geacintov, and V. Shafirovich (2008) Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: Relationship between kinetics and distribution of alkali-labile lesions.  J. Phys. Chem. B, 112: 1834-1844.

Wang, L., S. Chen, T. Xu, K. Taghizadeh, J. Wishnok, X. Zhou, D. You, Z. Deng, P.C. Dedon (2007) Phosphorothioation of DNA in bacteria by dnd genes. Nat. Chem. Biol., 3: 709-710.

Dedon, P.C. (2007) The chemical toxicology of 2-deoxyribose oxidation in DNA. Chem. Res. Toxicol. 21: 206-219.

Kim MY, Zhou X, Delaney JC, Taghizadeh K, Dedon PC, Essigmann JM, Wogan GN (2007) AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector.  Chem. Res. Toxicol.  20: 1075-1083.

Dedon, P.C., M. DeMott, E. Elmquist, E. Prestwich, B. Pang, J. McFaline (2007) The challenges of developing DNA and RNA biomarkers of inflammation.  Biomarkers Med., 1: 293-312.

Chen, B., Z. Xinfeng Zhou, K. Taghizadeh, J. Chen, J. Stubbe and P.C. Dedon (2007) GC-MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4'-oxidation of deoxyribose: Application to DNA damage produced by g-radiation and bleomycin.  Chem. Res. Toxicol., 20: 1701-1708.

Lee, Y.A., B.H. Yun, S.K. Kim, Y. Margolin, P.C. Dedon, N.E. Geacintov and V. Shafirovich (2007) Mechanisms of guanine oxidation in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate.  Chemistry 3: 4571-4581.

Yun BH, Lee YA, Kim SK, Kuzmin V, Kolbanovskiy A, Dedon PC, Geacintov NE, Shafirovich V. (2007) Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage. J. Am. Chem. Soc.  129: 9321-9332.

Pang, B., X. Zhou, H. Yu, M. Dong, K. Taghizadeh, J.S. Wishnok, S.R. Tannenbaum and P.C. Dedon (2007) Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation.  Carcinogenesis, 28: 1807-1813.

Jiang, T., X. Zhou, K. Taghizadeh, M. Dong and P.C. Dedon (2007) N-Formylation of lysines in histone proteins: A novel secondary modification arising from oxidative DNA damage.  Proc. Natl. Acad. Sci. USA, 104: 60-65.

Fry, R.C., M. DeMott, J.P. Cosgrove, T.J. Begley, L.D. Samson and P.C. Dedon (2006) The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.  BMC Genomics 7: 313.

Dedon, P.C. and M.C. Barth (2006) Oxidatively damaged DNA and inflammation, in Oxidative Damage to Nucleic Acids, ed. M. Evans and M. Cooke, Landes Bioscience/Eurekah.com, Austin, TX.

Margolin, Y., and P.C. Dedon (2006) A general method for quantifying sequence effects on nucleobase oxidation in DNA, in Methods in Molecular Biology, ed. R. Uppu, Humana Press, Totowa, NJ.

Reiter, T.A., B. Pang, P.C. Dedon, and B. Demple (2006) Resistance to nitric oxide-induced necrosis in heme oxygenase-1 over-expressing pulmonary epithelial cells associated with decreased lipid peroxidation.  J. Biol. Chem., 281: 36603-36612.
 
Chen, B., C.C. Vou, M.C. Byrns, P.C. Dedon, and L.A. Peterson (2006) Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytosine in oxidized DNA.  Chem. Res. Toxicol., 19: 982-985.

Margolin, Y., J.-F. Cloutier, V. Shafirovich, N. Geacintov and P.C. Dedon (2006) Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. Nature Chem. Biol., 2: 365-366.

Zipes, D.P., M.A. Pfeffer, N.J. Zvaifler, R.J. Glassock, S. Gilman, A. Muñoz, V. Gogolak, L. Gordis, P.C. Dedon, F.P. Guengerich, S.I. Wasserman, J.L. Witztum, and G.N. Wogan (2006) Rosuvastatin: An independent analysis of risks and benefits.  MedGenMed, 8: 73; available at: http://medgenmed.medscape.com/viewarticle/533930.

Li, C.-Q., B. Pang, T. Kiziltepe, L.J. Trudel, B.P. Engelward,P.C. Dedon, and G.N. Wogan (2006) Threshold cytotoxicity and genotoxicity induced by nitric oxide in human lymphoblastoid cells expressing wild-type or null p53.  Chem. Res. Toxicol., 19: 399-406.

Dong, M. and P.C. Dedon (2006) Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide.  Chem. Res. Toxicol. 19: 50-57.

Dedon, P., M. Barth, B. Chen, M. DeMott, V. Dendroulakis, M. Dong, S. Kalinga, E. Elmquist, Y. Margolin, B. Pang, X. Zhou (2006) Diverse mechanisms of endogenous nucleobase deamination in DNA and RNA, in Advances in Molecular Toxicology, ed. J. Fishbein, Wiley, NY.

Dong, M., V. Vongchampa, L. Gingipalli, J.-F. Cloutier, Y.W. Kow, T. O'Connor and P.C. Dedon (2006) Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species. Mut. Res. 594:120-134.